In this examine all knowledge on the HPV prevalence and types among women with normal cervical cytology, premalignant lesions, and cervical cancer obtained and pooled in Iran. The total HPV prevalence was discovered to be 9% in women with normal cervix, 55% in atypical squamous cells of undetermined significance or atypia instances, 58% and 69% in women with low and excessive grade squamous intraepithelial lesions, respectively, and 81% among women with invasive cervical cancer. In all of studied teams, HPV 16 was the commonest HPV types, adopted by HPV 18. In conclusion, this meta-analysis had revealed that if present HPV vaccines will combine into nationwide vaccination packages of Iran, it’s helpful.
Diagnostic use of fine-needle aspiration cytology and core-needle biopsy in head and neck sarcomas
The diagnostic position of fine-needle aspiration cytology (FNAC) and core-needle biopsy (CNB) has not been comprehensively assessed in head and neck sarcomas. A systematic overview of printed instances (1990-2020) was carried out. Diagnostic efficiency of each FNAC/CNB to find out tumor dignity and histopathological analysis was calculated. One hundred and sixty-eight instances had been included for which FNAC (n = 156), CNB (n = 8), or each (n = 4) had been used.
Predominant histologies had been skeletal muscle, chondrogenic and vascular sarcomas. FNAC accurately assessed dignity in 76.3% and histology in 45% of instances. Dignity was considerably higher for vascular tumors, metastatic and recurrent specimens, and worse for chondrogenic sarcomas. CNB confirmed a 92% accuracy to establish dignity and 83% for histopathology. FNAC and CNB are helpful strategies for the analysis of head and neck sarcomas, notably well-suited within the context of recurrent or metastatic illness. The position of CNB stays largely unexplored for this indication.
Tzanck cytology smear in analysis of cutaneous talaromycosis (penicilliosis)
Talaromyces marneffei an infection is an AIDS-defining sickness in South and Southeast Asia. Travel-related talaromycosis is being more and more acknowledged in non-endemic areas too. It is a doubtlessly deadly an infection with speedy deterioration, if left untreated. Usage of Tzanck cytology smear for speedy analysis of T. marneffei isn’t described. In this case examine, we report a person who offered with altered behaviour, headache, fever and cutaneous lesions.
Tzanck smear take a look at, pores and skin biopsy and blood tradition confirmed presence of T. marneffei. The cytomorphology findings of T. marneffei in Tzanck cytology smear had been described. In conclusion, Tzanck smear is an easy and cheap take a look at in establishing a speedy medical analysis of talaromycosis earlier than the tradition is reported.
Diagnostic Accuracy of Intraoperative Touch Imprint Cytology for the Diagnosis of Axillary Sentinel Lymph Node Metastasis of Breast Cancer: Comparison With Intraoperative Frozen Section Evaluation
Introduction The intraoperative frozen part is a beneficial technique to detect breast cancer metastasis to axillary sentinel lymph nodes (SLNs); nonetheless, frozen part shouldn’t be extensively obtainable and requires an skilled employees. Alternatively, contact imprint cytology (TIC) is an easy and cost-effective method to detect metastasis. Therefore, on this examine, we assessed the diagnostic accuracy of TIC for detecting SLN metastasis and in contrast it with intraoperative frozen part analysis.
Methodology A retrospective examine was carried out within the Department of Histopathology, Liaquat National Hospital and Medical College, for a length of two years. A whole of 114 sufferers present process surgical procedure for main breast cancer had been included within the examine. All sufferers had clinically and radiologically unfavorable axillary lymph nodes. SLN sampling was accomplished utilizing radioactive dye and despatched for intraoperative session.
The SLNs had been sliced at 4-mm intervals and two TIC slides and three step-levels for frozen part had been ready, and the outcomes had been in contrast with closing (paraffin) part histology. Results The sensitivity, specificity, and diagnostic accuracy of TIC was 83.7%, 98.5%, and 92.1%, respectively. Alternatively, the sensitivity, specificity, and diagnostic accuracy of frozen part was 93.9%, 100%, and 97.4%, respectively. The sensitivity of TIC and frozen part for detecting micrometastasis was 14.3% and 57.1%, respectively, with a diagnostic accuracy of 90.3% and 95.8%, respectively.
Alternatively, with respect to macrometastasis, the sensitivity and specificity of TIC had been 95.2% and 98.5%, respectively, whereas the sensitivity and specificity of frozen part had been 100%. Conclusion TIC is a fast and efficient method for detecting breast cancer metastasis in axillary SLNs. Although frozen part had an total increased sensitivity than TIC, the sensitivity of TIC for detecting macrometastasis was similar to the frozen part. Therefore, we conclude that TIC is an efficient various to the frozen part in services the place the frozen part shouldn’t be obtainable.
Atypical de Quervain’s thyroiditis recognized as atypia of undetermined significance by cytology and suspicious for cancer by Afirma Genomic Sequencing Classifier
We report a case of atypical de Quervain’s thyroiditis recognized as atypia of undetermined significance by cytology and suspicious for cancer by Afirma Genomic Sequencing Classifier. A 71-year-old male underwent thyroid ultrasound for goiter and was discovered to have two American Thyroid Association (ATA) 2015 high-suspicion nodules.
The bigger, 2.2-cm nodule was biopsied and the cytology confirmed atypical follicular cells and histiocytes. The Afirma Genomic Sequencing Classifier (detecting mRNA expression profile) end result was ”suspicious” (danger of malignancy ~50%) however Afirma Xpression Atlas (detecting particular mutations) didn’t discover mutations in BRAF V600E, RET/PTC1, or RET/PTC3. The affected person noticed two endocrine surgeons and two endocrinologists who every beneficial hemithyroidectomy.
The affected person selected to observe the nodules. A new diagnostic ultrasound carried out Three months after the primary one confirmed that the thyroid was considerably smaller and the beforehand seen nodules had been not discovered. Re-examination of the mobile smears confirmed that the cytological findings had been additionally suitable with de Quervain’s thyroiditis.
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This case illustrates that atypical de Quervain’s thyroiditis ought to be within the differential analysis of thyroid nodules for cytologists, radiologists, and clinicians. Furthermore, this case demonstrates that atypical de Quervain’s thyroiditis can generate false optimistic outcomes of molecular assessments for indeterminate thyroid nodules.